What does it do?

Ciclosporin is an immunosuppressant medicine used to treat some types of arthritis, kidney and skin problems. It is also sometimes used for other conditions.

How should you take it?

Take ciclosporin regularly as directed.
Measure the liquid carefully with the syringe supplied and add to a glass of apple or orange juice (do not use grapefruit juice or paper/polystyrene cups). Stir well and drink straight away. To make sure you get the full dose, add some more juice to the glass and drink that too.
Wipe the outside of the syringe with a dry tissue after use – do not rinse. Do not refrigerate ciclosporin liquid.

What if you forget a dose?

Take the missed dose as soon as possible. If it is close to the time for your next dose, skip the missed dose and carry on as normal. Do not take two doses at the same time.

Can you take other medicines?

Some medicines available without a prescription may react with ciclosporin including:

• anti-inflammatories, such as diclofenac (e.g. Voltaren®), ibuprofen (e.g. Nurofen®), or aspirin (e.g. Disprin®, in doses used for pain relief). These can also be found in some cold and flu medicines (e.g. Nurofen Cold and Flu®).
• levonorgestrel emergency contraceptive pill (e.g. Postinor-1®)
• orlistat (Xenical®)

Tell your pharmacist or doctor about all medicines or treatments that you may be taking, including vitamins, herbal products (e.g. echinacea, St John's wort) or recreational drugs.

What side effects might you notice?

Side Effects	Recommended action
Increased risk of infection - symptoms may include: fever, chills, sore throat, aches and pains, tiredness, pain when peeing, mouth ulcers Easy/unusual bruising or bleeding Seizures Symptoms of liver problems including: yellow skin or eyes, itching, dark urine, pale bowel motions, abdominal pain	Tell your doctor immediately
Changes in vision, confusion Enlarged, tender or bleeding gums Joint, muscle or bone aches and pains, tremor, tingling or numbness Peeing more often, feeling thirsty	Tell your doctor
Increased body hair, acne or oily skin Swollen feet or legs Headache Nausea, vomiting, diarrhoea, stomach pain	Tell your doctor if troublesome

If you notice any other effects, discuss them with your doctor or pharmacist.

Other information:

• Tell your doctor if you have liver, kidney or blood pressure problems, diabetes or gout; or if you have taken immunosuppressant medicines in the past.
• Tell your doctor if you have a long-term infection e.g. tuberculosis, HIV or hepatitis B or C.
• Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
• You will need regular blood tests to measure the amount of ciclosporin in your blood.
• Protect yourself from too much sunlight while taking immunosuppressant medicines (they may increase your risk of skin cancer). Always cover up and apply a thick layer of broad spectrum sunscreen (at least SPF30) when outside. Do not use sunbeds.
• Grapefruit, grapefruit juice or sour/Seville oranges may react with ciclosporin. Discuss with your pharmacist.
• You have an increased risk of getting an infection while taking ciclosporin. Discuss with your doctor.
• Talk to your health professional before having any vaccines. Avoid live vaccines while taking ciclosporin.
• It is important to tell anyone who gives you medical or dental treatment that you are taking ciclosporin.